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LCS3

CAT: 0013-GTR19188030-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188030-01Size:1 mg
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Description
LCS3 is a reversible, non-competitive dual inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with respective IC50 values of 3.3 μM and 3.8 μM. This compound exhibits antitumor activity by inducing apoptosis and is a useful research tool for studying lung adenocarcinoma (LUAD) in both cellular and animal models.
CAS Number
109844-92-0
Product Name Alternative
Cytosolic thioredoxin reductase 1 (TXNRD1), Apoptosis, Glutathione reductase, Glutathionereductase
Field of Research
Cell Biology, Metabolism Research
Purity
99.68% (May vary between batches)
Solubility
DMSO:112.5 mg/mL (421.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15 mM)
Smiles
[O-][N+] (=O) C1=CC=C (O1) C (=O) NC1=CC=C (Cl) C=C1
Molecular Formula
C11H7ClN2O4
Molecular Weight
266.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide

LCS3 is a reversible and uncompetitive glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) inhibitor (IC50=3.3 uM and 3.8 uM, respectively). LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research.

CAS Number109844-92-0
PubChem CID844044
IUPAC NameN-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
Molecular FormulaC11H7ClN2O4
Molecular Weight266.64
XLogP2.9
Topological Polar Surface Area88.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity325
SMILES
C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])Cl
InChI
InChI=1S/C11H7ClN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
InChIKey
JDBZJNUHQINERI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
CAS: 109844-92-0
CID: 844044
Formula: C11H7ClN2O4
MW: 266.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight266.64
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass266.0094344
Monoisotopic Mass266.0094344
Topological Polar Surface Area88.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity325
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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