Products for Research Use Only
RegisterLogin

LCS3

CAT: 0931-T60446-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T60446-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
109844-92-0
Target
Glutathione reductase, Apoptosis
Related Pathways
Apoptosis, Oxidation-Reduction
Purity
0.9984
Bioactivity
LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 μM and 3.8 μM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD) .
Smiles
[O-][N+](=O)C1=CC=C(O1)C(=O)NC1=CC=C(Cl)C=C1
Molecular Formula
C11H7ClN2O4
Molecular Weight
266.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide

LCS3 is a reversible and uncompetitive glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) inhibitor (IC50=3.3 uM and 3.8 uM, respectively). LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research.

CAS Number109844-92-0
PubChem CID844044
IUPAC NameN-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
Molecular FormulaC11H7ClN2O4
Molecular Weight266.64
XLogP2.9
Topological Polar Surface Area88.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity325
SMILES
C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])Cl
InChI
InChI=1S/C11H7ClN2O4/c12-7-1-3-8(4-2-7)13-11(15)9-5-6-10(18-9)14(16)17/h1-6H,(H,13,15)
InChIKey
JDBZJNUHQINERI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
CAS: 109844-92-0
CID: 844044
Formula: C11H7ClN2O4
MW: 266.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight266.64
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass266.0094344
Monoisotopic Mass266.0094344
Topological Polar Surface Area88.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity325
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T60386-01LCS-1

Alternative Products

CatalogName
BUP04756-01LCS3

Popular Products