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PF-543

CAT: 0013-GTR19187609-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187609-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-543 is a potent and selective sphingosine-competitive inhibitor of Sphingosine Kinase 1 (SphK1), exhibiting an IC50 of 2.0 nM and a Ki of 3.6 nM. This cell-permeable compound is a valuable research tool for investigating the role of SphK1 and sphingosine-1-phosphate signaling in cancer, inflammation, and fibrosis in both cellular and animal models.
CAS Number
1415562-82-1
Product Name Alternative
Lysophospholipid Receptor, PAH, necrosis, inhibit, LPL, LPLReceptor, LPL Receptor, Nrf-2, Inhibitor, Autophagy, anti-cancer, anti-inflammatory, Apoptosis, caspase-3/7, SphK, Sphingosine kinase, Sphingosine Kinase 1 Inhibitor II, sphingosine-competitive, SphK1, S1P Receptor, S1PReceptor, S1P, PF-543, PF543, PF 543, SK1
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.02% (May vary between batches)
Solubility
H2O:<1 mg/mL;10% DMSO+90% Corn Oil:5 mg/mL (10.74 mM) ; DMSO:93 mg/mL (199.74 mM) ; Ethanol:93 mg/mL (199.74 mM)
Smiles
Cc1cc (CS (=O) (=O) c2ccccc2) cc (OCc2ccc (CN3CCC[C@@H]3CO) cc2) c1
Molecular Formula
C27H31NO4S
Molecular Weight
465.6
Storage Conditions
-20°C
Notes
For research use only.

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