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AX-024

CAT: 0013-GTR19187494-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187494-01Size:2 mg
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Description
AX-024 is a potent and selective orally bioavailable small molecule inhibitor of the TCR-Nck interaction, targeting SH3 domains to suppress T cell activation. With an IC50 of ~1 nM, it effectively reduces pro-inflammatory cytokine production (e.g., IL-6, TNF-α, IFN-γ) and demonstrates low acute toxicity, making it a valuable tool for researching T-cell-mediated diseases in both cellular and animal models.
CAS Number
1370544-73-2
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
COc1ccc2OCC (CN3CCCC3) =C (c3ccc (F) cc3) c2c1
Molecular Formula
C21H22FNO2
Molecular Weight
339.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AX-024
CAS Number1370544-73-2
PubChem CID56949412
IUPAC Name1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine
Molecular FormulaC21H22FNO2
Molecular Weight339.4
XLogP3.4
Topological Polar Surface Area21.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity480
SMILES
COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4
InChI
InChI=1S/C21H22FNO2/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23/h4-9,12H,2-3,10-11,13-14H2,1H3
InChIKey
VMMKGVRPILDZML-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AX-024
CAS: 1370544-73-2
CID: 56949412
Formula: C21H22FNO2
MW: 339.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight339.4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass339.16345711
Monoisotopic Mass339.16345711
Topological Polar Surface Area21.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
VEC54473-01AX-024
S6727-2mgAX-024 HCl
A16926-50AX-024 50mg
B2013-5AX-024 hydrochloride
A16926-100AX-024 100mg
A16926-25AX-024 25mg
A16926-10AX-024 10mg
A16926-5AX-024 5mg
A16926-2AX-024 2mg

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