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RUNX1/ETO tetramerization-IN-1

CAT: 0013-GTR19187465-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187465-01Size:2 mg
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Description
RUNX1/ETO tetramerization-IN-1 is a potent small-molecule inhibitor that disrupts the NHR2-mediated tetramerization of the RUNX1/ETO oncoprotein (EC50 = 0.25 μM) . It restores downregulated gene expression, inhibits RUNX1/ETO-dependent leukemia cell proliferation in vitro, and demonstrates significant anti-tumor efficacy in mouse models of AML.
CAS Number
88755-39-9
Field of Research
Cancer Biology
Smiles
C (CC (=O) C=1C=C2C (=CC1) OCO2) (C (O) =O) C=3C=C4C (=CC3) OCO4
Molecular Formula
C18H14O7
Molecular Weight
342.3
Storage Conditions
-20°C
Notes
For research use only.

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