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HPK1-IN-17

CAT: 0013-GTR19186053-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186053-01Size:25 mg
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Description
HPK1-IN-17 is a potent and selective small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1), a MAP4K family member. This compound is a valuable research tool for investigating HPK1's role in immunology and oncology, supporting both in vitro cellular studies and in vivo preclinical cancer research.
CAS Number
2403600-07-5
Field of Research
Signal Transduction
Smiles
C (N (C) C) (=O) C1=CC=C (C=2C=3C (NC2) =NC=C (N3) C4=CC=C (C=C4) N5CCN (C) CC5) C=C1
Molecular Formula
C26H28N6O
Molecular Weight
440.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Hpk1-IN-17
CAS Number2403600-07-5
PubChem CID146274358
IUPAC NameN,N-dimethyl-4-[2-[4-(4-methylpiperazin-1-yl)phenyl]-5H-pyrrolo[2,3-b]pyrazin-7-yl]benzamide
Molecular FormulaC26H28N6O
Molecular Weight440.5
XLogP3
Topological Polar Surface Area68.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity649
SMILES
CN1CCN(CC1)C2=CC=C(C=C2)C3=CN=C4C(=N3)C(=CN4)C5=CC=C(C=C5)C(=O)N(C)C
InChI
InChI=1S/C26H28N6O/c1-30(2)26(33)20-6-4-18(5-7-20)22-16-27-25-24(22)29-23(17-28-25)19-8-10-21(11-9-19)32-14-12-31(3)13-15-32/h4-11,16-17H,12-15H2,1-3H3,(H,27,28)
InChIKey
UGFRQKYVEWFPGO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hpk1-IN-17
CAS: 2403600-07-5
CID: 146274358
Formula: C26H28N6O
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass440.23245954
Monoisotopic Mass440.23245954
Topological Polar Surface Area68.4 Ų
Heavy Atom Count33
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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