Products for Research Use Only
RegisterLogin

G12Si-5

CAT: 0013-GTR19185512-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19185512-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
G12Si-5 is a covalent inhibitor targeting the K-RasG12S mutant, binding its S-IIP domain with a Ki of 26 μM to suppress oncogenic signaling. It effectively reduces ERK phosphorylation in KRAS G12S mutant cell lines, making it a valuable tool for in vitro cancer research, though its powder form is unstable, necessitating stabilized salt formulations.
CAS Number
2946593-46-8
Field of Research
Signal Transduction
Smiles
C (OC=1N=C (C2=C (N1) C (F) =C (N=C2) C=3C4=C (C=CC3) C=CC=C4Cl) N5C[C@]6 ([C@@] (CC5) (C (=O) O6) [H]) [H]) C78N (CCC7) CCC8
Molecular Formula
C31H29ClFN5O3
Molecular Weight
574.05
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19184863-01G12Si-1
GTR19220809-01G12Si-2
GTR180271485.5 Antibody
GTR19230899-015-LOX-IN-5
GTR19221943-015,5'-Dimethoxysecoisolariciresinol
GTR180271505.5 Antibody
GTR180270775.5 Antibody
GTR19235383-01FABP4/5-IN-5
GTR19182420-015,5'-Dimethoxylariciresinol
GTR19261971-01(RS) -G12Di-1

Alternative Products

CatalogName
T64059-01G12Si-5
T74920-01G12Si-2
T63758-01G12Si-1
sc-2627255,5,5-Trifluorovaleronitrile
234404-015,5,5-Trifluoronorvaline
PDA866615,5,5-Trifluoropentanonitrile
JH2382995,5,5-trifluoroleucine
AKA25347-015,5,5-Trifluoropentanal
TRC-F632600-2.5GN-Fmoc-5,5,5,5',5',5'-Hexafluoro-L-leucine
OR1058406-015,5',5'',5'''-Methanetetrayltetrakis (2-hydroxybenzaldehyde)

Popular Products