WYE-687

CAT: 0013-GTR19184297-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0013-GTR19184297-01Size:1 ml x 10 mM (in DMSO)

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

WYE-687 is a potent and selective ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It effectively suppresses mTORC1 and mTORC2 signaling by inhibiting pS6K (T389) and pAKT (S473), respectively, while showing high selectivity over PI3K isoforms. This inhibitor is a valuable tool for studying mTOR-dependent pathways in cancer and metabolic disease research, both in vitro and in vivo.

CAS Number

1062161-90-3

Product Name Alternative

Inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, p38α, p38MAPK, p38 MAPK, PI3K, WYE687, WYE-687, WYE 687, PI3Kα, PI3Kγ, Phosphoinositide 3-kinase, Src

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.98% (May vary between batches)

Solubility

H2O:60.2 mg/mL (113.88 mM) ; DMSO:60.2 mg/mL (113.88 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.78 mM)

Smiles

COC (=O) Nc1ccc (cc1) -c1nc (N2CCOCC2) c2cnn (C3CCN (Cc4cccnc4) CC3) c2n1

Molecular Formula

C28H32N8O3

Molecular Weight

528.61

Storage Conditions

-20°C

Notes

For research use only.

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022895	WYE-687
MBS132286-01	WYE 687

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