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WYE-354

CAT: 0013-GTR19163965-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163965-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR), displays >100-fold selectivity over PI3K isofoms; acutely blocks substrate phosphorylation by mTORC1 and mTORC2 in vitro and in cells in response to growth factor, amino acids, and hyperactive PI3K/AKT, reduces AKT downstream function and inhibits proliferation of diverse cancer cell lines; inhibits mTORC1 and mTORC2 and displayed robust antitumor activity in PTEN-null tumors.
CAS Number
1062169-56-5
Product Name Alternative
WYE 354 | WYE354
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 26 mg/mL
Smiles
O=C (N1CCC (N2N=CC3=C (N4CCOCC4) N=C (C5=CC=C (NC (OC) =O) C=C5) N=C32) CC1) OC
Molecular Formula
C24H29N7O5
Molecular Weight
495.5309
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperidinecarboxylic acid, 4-[6-[4-[ (methoxycarbonyl) amino]phenyl]-4- (4-morpholinyl) -1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester

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