WYE-354

CAT: 0013-GTR19168134-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19168134-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

WYE-354 is a potent, selective, and ATP-competitive mTOR inhibitor with an IC50 of 5 nM. It effectively suppresses mTORC2-mediated P-AKT (S473) and mTORC1-mediated P-S6K (T389) signaling, demonstrating high selectivity over PI3K isoforms. This inhibitor is a valuable tool for investigating mTOR pathway biology in both cellular and in vivo cancer research models.

CAS Number

1062169-56-5

Product Name Alternative

Autophagy, Apoptosis, inhibit, mTOR, Inhibitor, Mammalian target of Rapamycin, WYE 354, WYE-354, PI3Kα, WYE354, PI3Kγ

Field of Research

Cell Biology, Signal Transduction

Purity

97.86% (May vary between batches)

Solubility

Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:92 mg/mL (185.66 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.02 mM)

Smiles

COC (=O) Nc1ccc (cc1) -c1nc (N2CCOCC2) c2cnn (C3CCN (CC3) C (=O) OC) c2n1

Molecular Formula

C24H29N7O5

Molecular Weight

495.53

Storage Conditions

-20°C

Notes

For research use only.

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A1266-10	WYE-354
TRC-W950000-500MG	WYE 354

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