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NRX-2663

CAT: 0013-GTR19186429-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186429-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NRX-2663 is a small molecule that potently enhances the interaction between β-catenin and the SCFβ-TrCP E3 ubiquitin ligase complex, with a reported Kd of 54.8 nM and an EC50 of 22.9 nM. This compound is a valuable research tool for studying Wnt/β-catenin signaling, protein degradation mechanisms, and has utility in both in vitro biochemical assays and cellular models of oncogenesis.
CAS Number
2763260-34-8
Field of Research
Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O (C1=C (C (NC2=CC (C (O) =O) =CC=C2) =O) C (=O) NC (C (F) (F) F) =C1) C3=CC=CC=C3
Molecular Formula
C20H13F3N2O5
Molecular Weight
418.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-{[2-Oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid
CAS Number2763260-34-8
PubChem CID137628321
IUPAC Name3-[[2-oxo-4-phenoxy-6-(trifluoromethyl)-1H-pyridine-3-carbonyl]amino]benzoic acid
Molecular FormulaC20H13F3N2O5
Molecular Weight418.3
XLogP2.9
Topological Polar Surface Area105
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity769
SMILES
C1=CC=C(C=C1)OC2=C(C(=O)NC(=C2)C(F)(F)F)C(=O)NC3=CC=CC(=C3)C(=O)O
InChI
InChI=1S/C20H13F3N2O5/c21-20(22,23)15-10-14(30-13-7-2-1-3-8-13)16(18(27)25-15)17(26)24-12-6-4-5-11(9-12)19(28)29/h1-10H,(H,24,26)(H,25,27)(H,28,29)
InChIKey
QMARDTCIJVODCK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-{[2-Oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid
CAS: 2763260-34-8
CID: 137628321
Formula: C20H13F3N2O5
MW: 418.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.3
XLogP32.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass418.07765601
Monoisotopic Mass418.07765601
Topological Polar Surface Area105 Ų
Heavy Atom Count30
Formal Charge0
Complexity769
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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