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NRX-252262

CAT: 0013-GTR19165736-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165736-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NRX-252262 is a small molecule that potently enhances the interaction between β-catenin and the SCFβ-TrCP E3 ligase, leading to targeted degradation of mutant β-catenin with an EC50 of 3.8 nM. It serves as a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has demonstrated proof-of-concept efficacy in cellular models of oncogenesis.
CAS Number
2438637-61-5
Product Name Alternative
Beta catenin, betacatenin, beta-catenin, bcatenin, Inhibitor, inhibit, NRX252262, NRX-252262, NRX 252262, SCF (β-TrCP) -E3 ligase, Wnt/β-catenin, Wnt, Wnt/b-catenin, Wnt/betacatenin, βcatenin, β-catenin
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.94% (May vary between batches)
Solubility
DMSO:8 mg/mL (14.67 mM)
Smiles
COc1cc2CN (Cc2cc1OC) C (=O) c1c (Sc2c (Cl) cccc2Cl) cc ([nH]c1=O) C (F) (F) F
Molecular Formula
C23H17Cl2F3N2O4S
Molecular Weight
545.36
Storage Conditions
-20°C
Notes
For research use only.

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