Estradiol-d4

• Description :

  Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

• CAS Number :

  [66789-03-5]

• Product Name Alternative :

  β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4

• UNSPSC :

  12352005

• Hazard Statement :

  H351, H360, H362, H410

• Target :

  Endogenous Metabolite; Estrogen Receptor/ERR

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Endocrinology; Cancer

• Concentration :

  10mM

• Purity :

  99.55

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  C[C@@]12[C@](CC([2H])([2H])[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC([2H])=C(O)C([2H])=C4CC3

• Molecular Formula :

  C18H20D4O2

• Molecular Weight :

  276.41

• Precautions :

  H351, H360, H362, H410

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Woolley CS, et al. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci. 1997 Mar 1;17 (5) :1848-59.; Mermelstein PG, et al. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. J Neurosci. 1996 Jan 15;16 (2) :595-604.; Quanfu Huang, et al. 17β-estradiol Upregulates IL6 Expression Through the ERβ Pathway to Promote Lung Adenocarcinoma Progression. J Exp Clin Cancer Res. 2018 Jul 3;37 (1) :133.; Woolley CS, et al. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992 Jul;12 (7) :2549-54.; Woolley CS, et al. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J Comp Neurol. 1993 Oct 8;336 (2) :293-306.; Harburger LL, et al. Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice. Neuroscience. 2009;160 (1) :6-12.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported