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Nauclefine

CAT: 0013-GTR19178980-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178980-02Size:50 mg
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Description
Nauclefine (Parvine) is a natural indole alkaloid that triggers apoptosis in various cancer cells through a PDE3A-SLFN12-dependent mechanism, despite binding to PDE3A without inhibiting its enzymatic activity. It serves as a valuable research tool for studying this novel cell death pathway in both in vitro and in vivo oncology models.
CAS Number
57103-51-2
Product Name Alternative
Parvine, PDE3A, Nauclefine
Field of Research
Cell Biology, Metabolism Research
Purity
99.92% (May vary between batches)
Solubility
DMSO:20 mg/mL (69.61 mM)
Smiles
O=C1N2C (C3=C (C=4C (N3) =CC=CC4) CC2) =CC=5C1=CN=CC5
Molecular Formula
C18H13N3O
Molecular Weight
287.32
Storage Conditions
Store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Parvine

Parvine has been reported in Sarcocephalus latifolius and Nauclea orientalis with data available.

CAS Number57103-51-2
PubChem CID320217
IUPAC Name3,13,17-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15(20),16,18-octaen-14-one
Molecular FormulaC18H13N3O
Molecular Weight287.3
XLogP2.3
Topological Polar Surface Area49
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count22
Formal Charge0
Complexity516
SMILES
C1CN2C(=CC3=C(C2=O)C=NC=C3)C4=C1C5=CC=CC=C5N4
InChI
InChI=1S/C18H13N3O/c22-18-14-10-19-7-5-11(14)9-16-17-13(6-8-21(16)18)12-3-1-2-4-15(12)20-17/h1-5,7,9-10,20H,6,8H2
InChIKey
BGFQUYBVDVRJSP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Parvine
CAS: 57103-51-2
CID: 320217
Formula: C18H13N3O
MW: 287.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight287.3
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass287.105862047
Monoisotopic Mass287.105862047
Topological Polar Surface Area49 Ų
Heavy Atom Count22
Formal Charge0
Complexity516
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5788220Nauclefine

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