PHF6 (TFA)

• UNSPSC Description:

  PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein[1].

• Target Antigen:

  Amyloid-β; Autophagy

• Type:

  Peptides

• Related Pathways:

  Autophagy;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phf6-tfa.html

• Purity:

  99.03

• Solubility:

  H2O : ≥ 50 mg/mL

• Smiles:

  OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

• Molecular Weight:

  748.91 (free base)

• References & Citations:

  [1]Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10(7):1652.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported