PHF6

• Description:

  PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].

• UNSPSC:

  12352209

• Target:

  Amyloid-β; Autophagy

• Type:

  Peptides

• Related Pathways:

  Autophagy; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/phf6.html

• Purity:

  99.17

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O

• Molecular Formula:

  C36H60N8O9

• Molecular Weight:

  748.91

• References & Citations:

  [1]Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10 (7) :1652.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [329897-62-3]