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J-113863

CAT: 0013-GTR19177207-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177207-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
J-113863 is a potent and selective CCR1 antagonist with species-specific activity, showing high affinity for human CCR1 (IC50 0.9 nM) and mouse CCR1 (IC50 5.8 nM) . It also antagonizes human CCR3 but is much less active on the mouse ortholog, and is inactive against several other chemokine and inflammatory receptors. This profile makes it a valuable research tool for studying CCR1-mediated pathways in inflammation, autoimmunity, and fibrosis in both cellular and animal models.
CAS Number
353791-85-2
Product Name Alternative
Collagen, CCR1, CCR, CC chemokine receptor, CCR3, Chemotaxis, CD18, arthritis, anti-inflammatory, Inhibitor, inhibit, J 113863, J113863, J-113863, rheumatoid
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
95.11% (May vary between batches)
Solubility
DMSO:6.56 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.53 mM)
Smiles
[I-].CC[N+]1 (C\C2=C\CCCCCC2) CCC (CC1) NC (=O) C1c2cc (Cl) ccc2Oc2ccc (Cl) cc12
Molecular Formula
C30H37Cl2IN2O2
Molecular Weight
655.44
Storage Conditions
-20°C
Notes
For research use only.

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