Products for Research Use Only
RegisterLogin

J-113863

CAT: 0013-GTR19177207-03Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19177207-03Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
J-113863 is a potent and selective CCR1 antagonist with species-specific activity, showing high affinity for human CCR1 (IC50 0.9 nM) and mouse CCR1 (IC50 5.8 nM) . It also antagonizes human CCR3 but is much less active on the mouse ortholog, and is inactive against several other chemokine and inflammatory receptors. This profile makes it a valuable research tool for studying CCR1-mediated pathways in inflammation, autoimmunity, and fibrosis in both cellular and animal models.
CAS Number
353791-85-2
Product Name Alternative
Collagen, CCR1, CCR, CC chemokine receptor, CCR3, Chemotaxis, CD18, arthritis, anti-inflammatory, Inhibitor, inhibit, J 113863, J113863, J-113863, rheumatoid
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Purity
95.11% (May vary between batches)
Solubility
DMSO:6.56 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.53 mM)
Smiles
[I-].CC[N+]1 (C\C2=C\CCCCCC2) CCC (CC1) NC (=O) C1c2cc (Cl) ccc2Oc2ccc (Cl) cc12
Molecular Formula
C30H37Cl2IN2O2
Molecular Weight
655.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

J-113863, trans-
CAS Number353791-85-2
PubChem CID6918496
IUPAC Name2,7-dichloro-N-[1-[[(1E)-cycloocten-1-yl]methyl]-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide iodide
Molecular FormulaC30H37Cl2IN2O2
Molecular Weight655.4
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity755
SMILES
CC[N+]1(CCC(CC1)NC(=O)C2C3=C(C=CC(=C3)Cl)OC4=C2C=C(C=C4)Cl)C/C/5=C/CCCCCC5.[I-]
InChI
InChI=1S/C30H36Cl2N2O2.HI/c1-2-34(20-21-8-6-4-3-5-7-9-21)16-14-24(15-17-34)33-30(35)29-25-18-22(31)10-12-27(25)36-28-13-11-23(32)19-26(28)29;/h8,10-13,18-19,24,29H,2-7,9,14-17,20H2,1H3;1H/b21-8+;
InChIKey
FOAFBMYSXIGAOX-LQGGPMKRSA-N
Chemical Structure
2D Structure
2D structure of J-113863, trans-
CAS: 353791-85-2
CID: 6918496
Formula: C30H37Cl2IN2O2
MW: 655.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight655.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass654.12768
Monoisotopic Mass654.12768
Topological Polar Surface Area38.3 Ų
Heavy Atom Count37
Formal Charge0
Complexity755
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR18717056Clusterin Antibody / Apolipoprotein J / APO-J
GTR18716697-01Clusterin Antibody / Apolipoprotein J / APO-J
GTR18717054Apolipoprotein J Antibody / APO-J / Clusterin
GTR19157832-01Gomisin J
GTR19179703Garcimultiflorone J
GTR19179587Mudanpioside J
GTR19179209Polygalin J
GTR19255513-01Moracin J
GTR19255290-01Hericenone J
GTR19254584-01Cathayanon J

Alternative Products

CatalogName
HY-103360-01J-113863
2595/1J 113863
HY-103360A-01Cis-J-113863
HY-103360B-01Trans-J-113863
TR512160Vmn1r15 Mouse shRNA Plasmid (Locus ID 113863)
SR408689Vmn1r15 Mouse siRNA Oligo Duplex (Locus ID 113863)
TL512160VVmn1r15 Mouse shRNA Lentiviral Particle (Locus ID 113863)
MBS6507007-01Apolipoprotein J (Apo J)

Popular Products