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CK-666

CAT: 0013-GTR19176874-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176874-01Size:5 mg
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Description
CK-666 is a cell-permeable small molecule that potently inhibits the Arp2/3 complex by stabilizing its inactive state, preventing the conformational change required for actin nucleation. This inhibitor is widely used in cell biology research to study actin cytoskeleton dynamics in processes such as cell motility, endocytosis, and pathogen invasion in both in vitro and in vivo models.
CAS Number
442633-00-3
Product Name Alternative
CK666, CK-666, CK 666, allosteric, active, Actin-related protein 2/3 complex, Arp2/3 Complex, Arp2/3 complex, MicrotubuleAssociated, Microtubule Associated, Inhibitor, inhibit, meshwork, effector, HIV Protease, HIV, HIVProtease, Human immunodeficiency virus, state, trabecular
Field of Research
Neuroscience
Purity
>98%
Bioactivity
ARP2/3 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 30 mg/ml) .
Smiles
Cc1[nH]c2ccccc2c1CCNC (=O) c1ccccc1F
Molecular Formula
C18H17FN2O
Molecular Weight
296.34
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-Fluoro-N-[2-methyl-1H-indol-3-yl) ethyl]benzamide

Chemical Information

CK-666

CK-666 is a member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation. It has a role as an actin polymerisation inhibitor. It is a member of benzamides, a member of indoles and an organofluorine compound.

CAS Number442633-00-3
PubChem CID589075
IUPAC Name2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Molecular FormulaC18H17FN2O
Molecular Weight296.3
XLogP3.8
Topological Polar Surface Area44.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count22
Formal Charge0
Complexity389
SMILES
CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
InChI
InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChIKey
UXRKUKRXVWJFER-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CK-666
CAS: 442633-00-3
CID: 589075
Formula: C18H17FN2O
MW: 296.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass296.13249133
Monoisotopic Mass296.13249133
Topological Polar Surface Area44.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity389
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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