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T6167923

CAT: 0013-GTR19175732-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175732-01Size:1 mg
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Description
T6167923 is a potent and selective small molecule inhibitor that targets the MyD88 TIR domain, blocking homodimerization and downstream NF-κB signaling. It demonstrates anti-inflammatory activity in vitro by suppressing key cytokines including IFN-γ, IL-1β, IL-6, and TNF-α. This inhibitor is a valuable research tool for studying Toll-like receptor and interleukin-1 receptor pathways in inflammatory and autoimmune disease models.
CAS Number
2437475-16-4
Product Name Alternative
T 6167923, T6167923, T-6167923, MyD88
Field of Research
Immunology & Inflammation
Purity
99.23% (May vary between batches)
Solubility
DMSO:250 mg/mL (545.39 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.91 mM)
Smiles
C[C@H] (NC (=O) N1CCN (CC1) S (=O) (=O) c1cccc (Br) c1) c1cccs1
Molecular Formula
C17H20BrN3O3S2
Molecular Weight
458.39
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 25648555
CAS Number2437475-16-4
PubChem CID25648555
IUPAC Name4-(3-bromophenyl)sulfonyl-N-[(1S)-1-thiophen-2-ylethyl]piperazine-1-carboxamide
Molecular FormulaC17H20BrN3O3S2
Molecular Weight458.4
XLogP2.5
Topological Polar Surface Area106
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity591
SMILES
C[C@@H](C1=CC=CS1)NC(=O)N2CCN(CC2)S(=O)(=O)C3=CC(=CC=C3)Br
InChI
InChI=1S/C17H20BrN3O3S2/c1-13(16-6-3-11-25-16)19-17(22)20-7-9-21(10-8-20)26(23,24)15-5-2-4-14(18)12-15/h2-6,11-13H,7-10H2,1H3,(H,19,22)/t13-/m0/s1
InChIKey
PNTQVMBKHCOLQD-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of CID 25648555
CAS: 2437475-16-4
CID: 25648555
Formula: C17H20BrN3O3S2
MW: 458.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.4
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass457.01295
Monoisotopic Mass457.01295
Topological Polar Surface Area106 Ų
Heavy Atom Count26
Formal Charge0
Complexity591
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5753995T6167923
M33136-01T6167923 B

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