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T6167923 B

CAT: 1410-M33136-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M33136-01Size:1 g
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Description
T6167923 is a potent, selective inhibitor of MyD88-dependent signaling pathways. It achieves this by directly binding to the Toll/IL1 receptor (TIR) domain of MyD88, preventing MyD88 homodimer formation. Subsequently, T6167923 impedes NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity and boasts improved anti-inflammatory effects, with IC50s values of 2.7 μM for IFN-γ, 2.9 μM for IL-1β, and 2.66 μM each for IL-6 and TNF-α, demonstrating its efficacy across multiple inflammatory mediators .
CAS Number
2437475-16-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
458.39
Molecular Formula
C17H20BrN3O3S2
Notes
Research use only, not for human use.
Receptor
MyD88

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