Cabergoline

CAT: 0013-GTR19175073-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19175073-01Size:1 mg

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Description

Cabergoline is an ergot-derived dopamine D2-like receptor agonist with high affinity for D2, D3, and 5-HT2B receptors. It is widely used in research to study prolactinoma treatment, enabling effective hormonal and tumor control in both in vitro and in vivo experimental models.

CAS Number

81409-90-7

Product Name Alternative

DopamineReceptor, Dopamine Receptor, Dopamine D3 receptor, Dopamine D2 receptor, Dopamine, D3, D2, 5HTReceptor, 5HT Receptor, 5-HT2B, 5-HT2B receptor, Autophagy, Cabergoline, FCE21336, FCE-21336, FCE 21336, Inhibitor, inhibit

Field of Research

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Purity

97.69% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.43 mM) ; DMSO:260 mg/mL (575.73 mM)

Smiles

[H][C@@]12Cc3c[nH]c4cccc (c34) [C@@]1 ([H]) C[C@H] (CN2CC=C) C (=O) N (CCCN (C) C) C (=O) NCC

Molecular Formula

C26H37N5O2

Molecular Weight

451.6

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Cabergoline

Cabergoline is an N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia. It has a role as an antineoplastic agent, an antiparkinson drug and a dopamine agonist.

CAS Number	81409-90-7
PubChem CID	54746
IUPAC Name	(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
Molecular Formula	C26H37N5O2
Molecular Weight	451.6
XLogP	3.4
Topological Polar Surface Area	71.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Heavy Atom Count	33
Formal Charge	0
Complexity	713

SMILES

CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

InChI

InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

InChIKey

KORNTPPJEAJQIU-KJXAQDMKSA-N

Chemical Structure

2D Structure

CAS: 81409-90-7

CID: 54746

Formula: C26H37N5O2

MW: 451.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	451.6
XLogP3	3.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	451.29472544
Monoisotopic Mass	451.29472544
Topological Polar Surface Area	71.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	713
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T14853-01	Cabergoline
HY-15296A	Cabergoline (diphosphate)
RM-C012713-01	Cabergoline-d6
sc-499163	Dihydro cabergoline

Cabergoline

Chemical Information

Alternative Products

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