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PF-249

CAT: 0013-GTR19174838-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174838-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-249 (PF-06685249) is a potent and β1-selective AMPK activator, demonstrating an EC50 of 12 nM for the α1β1γ1 isoform. This small molecule is a valuable research tool for investigating metabolic diseases, including studies on diabetic nephropathy in both cellular and animal models.
CAS Number
1467059-70-6
Product Name Alternative
AMPK α1β1γ1, PF 249, PF 06685249, PF06685249, PF-06685249, PF249, PF-249
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
97.01% (May vary between batches)
Solubility
DMSO:90 mg/mL (260.28 mM)
Smiles
COc1nc (ccc1-c1cc2c (c[nH]c2cc1Cl) C (O) =O) N (C) C
Molecular Formula
C17H16ClN3O3
Molecular Weight
345.78
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
CAS Number1467059-70-6
PubChem CID71767991
IUPAC Name6-chloro-5-[6-(dimethylamino)-2-methoxy-3-pyridinyl]-1H-indole-3-carboxylic acid
Molecular FormulaC17H16ClN3O3
Molecular Weight345.8
XLogP3.5
Topological Polar Surface Area78.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity464
SMILES
CN(C)C1=NC(=C(C=C1)C2=C(C=C3C(=C2)C(=CN3)C(=O)O)Cl)OC
InChI
InChI=1S/C17H16ClN3O3/c1-21(2)15-5-4-9(16(20-15)24-3)10-6-11-12(17(22)23)8-19-14(11)7-13(10)18/h4-8,19H,1-3H3,(H,22,23)
InChIKey
MJHBRTGGZYSCHJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
CAS: 1467059-70-6
CID: 71767991
Formula: C17H16ClN3O3
MW: 345.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.8
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass345.0880191
Monoisotopic Mass345.0880191
Topological Polar Surface Area78.5 Ų
Heavy Atom Count24
Formal Charge0
Complexity464
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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