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R406 free base

CAT: 0013-GTR19174830-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174830-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R406 free base is a selective and potent inhibitor of spleen tyrosine kinase (Syk) . It is widely used in biochemical and cellular research to investigate Syk-dependent signaling pathways in immunology and oncology, with applications in both in vitro assays and in vivo disease models.
CAS Number
841290-80-0
Product Name Alternative
Inhibitor, inhibit, FLT3, Fms like tyrosine kinase 3, Apoptosis, Cluster of differentiation antigen 135, CD135, Spleen tyrosine kinase, Syk, R406, R-406, R406 (free base), R406 free base, R-406 free base, R 406
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.12% (May vary between batches)
Solubility
DMSO:4.71 mg/mL (10.01 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
COc1cc (Nc2ncc (F) c (Nc3ccc4OC (C) (C) C (=O) Nc4n3) n2) cc (OC) c1OC
Molecular Formula
C22H23FN6O5
Molecular Weight
470.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tamatinib

6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one is a substituted aniline and a member of methoxybenzenes.

CAS Number841290-80-0
PubChem CID11213558
IUPAC Name6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
Molecular FormulaC22H23FN6O5
Molecular Weight470.5
XLogP3.1
Topological Polar Surface Area129
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity691
SMILES
CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
InChI
InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChIKey
NHHQJBCNYHBUSI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tamatinib
CAS: 841290-80-0
CID: 11213558
Formula: C22H23FN6O5
MW: 470.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.5
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass470.17139602
Monoisotopic Mass470.17139602
Topological Polar Surface Area129 Ų
Heavy Atom Count34
Formal Charge0
Complexity691
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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