Products for Research Use Only
RegisterLogin

R406

CAT: 0013-GTR19171674-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19171674-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
R406 besylate is a potent and selective inhibitor of spleen tyrosine kinase (Syk), demonstrating an IC50 of 41 nM with no activity against Lyn. This small molecule is a valuable research tool for studying Syk-dependent signaling pathways in immune cell activation, inflammation, and oncology, both in vitro and in preclinical in vivo models.
CAS Number
841290-81-1
Product Name Alternative
FLT3, Apoptosis, R 406, R406, R-406, Syk
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.67% (May vary between batches)
Solubility
Ethanol:8 mg/mL (12.73 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.36 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:100 mg/mL (159.08 mM)
Smiles
OS (=O) (=O) c1ccccc1.COc1cc (Nc2ncc (F) c (Nc3ccc4OC (C) (C) C (=O) Nc4n3) n2) cc (OC) c1OC
Molecular Formula
C22H23FN6O5·C6H6O3S
Molecular Weight
628.63
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

R406 Benzenesulfonate
CAS Number841290-81-1
PubChem CID11984591
IUPAC Namebenzenesulfonic acid;6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
Molecular FormulaC28H29FN6O8S
Molecular Weight628.6
Topological Polar Surface Area192
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Heavy Atom Count44
Formal Charge0
Complexity874
SMILES
CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O
InChI
InChI=1S/C22H23FN6O5.C6H6O3S/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4;7-10(8,9)6-4-2-1-3-5-6/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30);1-5H,(H,7,8,9)
InChIKey
UXDRJPYSTZHIOE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of R406 Benzenesulfonate
CAS: 841290-81-1
CID: 11984591
Formula: C28H29FN6O8S
MW: 628.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight628.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count8
Exact Mass628.17516124
Monoisotopic Mass628.17516124
Topological Polar Surface Area192 Ų
Heavy Atom Count44
Formal Charge0
Complexity874
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR18043224-01PAH (R400) polyclonal antibody
GTR18042584-01X11γ (R401) polyclonal antibody
GTR18041089-01NSE/Enolase (R400) polyclonal antibody
GTR18048350-01COX6c (R40) polyclonal antibody
GTR18042423-01Egr-1/2 (R409) polyclonal antibody
GTR18048619-01COX6c (R40) polyclonal antibody
GTR19104338-01Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R401 (MIMI_R401)
GTR19110193-01Recombinant Acanthamoeba polyphaga mimivirus Uncharacterized protein R40 (MIMI_R40)

Alternative Products

CatalogName
inh-r406nR406

Popular Products