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NSC-87877

CAT: 0013-GTR19174813-04Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174813-04Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC-87877 is a cell-permeable inhibitor of the SHP2 and SHP1 tyrosine phosphatases, with respective IC50 values of 0.318 μM and 0.355 μM, and it also suppresses DUSP26 activity. This compound is widely used in biochemical and cellular research to investigate phosphatase signaling roles in cancer, developmental biology, and immune regulation.
CAS Number
56990-57-9
Product Name Alternative
DUSP26, Apoptosis, Inhibitor, HSP27, inhibit, neuroblastoma, NSC87877, NSC-87877, NSC 87877, p53, Phosphatase, shp1, shp2, SHP-1, SHP-2, p38, PPAR
Field of Research
Cell Biology, Metabolism Research, Neuroscience
Purity
97.35% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.18 mM) ; DMSO:4 mg/mL (8.71 mM)
Smiles
Oc1c (cc (c2cccnc12) S (O) (=O) =O) \N=N\c1ccc2cc (ccc2c1) S (O) (=O) =O
Molecular Formula
C19H13N3O7S2
Molecular Weight
459.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Nsc-87877

8-oxo-7-[(6-sulfo-2-naphthalenyl)hydrazinylidene]-5-quinolinesulfonic acid is a naphthalenesulfonic acid.

CAS Number56990-57-9
PubChem CID92577
IUPAC Name8-hydroxy-7-[(6-sulfonaphthalen-2-yl)diazenyl]quinoline-5-sulfonic acid
Molecular FormulaC19H13N3O7S2
Molecular Weight459.5
XLogP2.4
Topological Polar Surface Area183
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count31
Formal Charge0
Complexity883
SMILES
C1=CC2=C(C=C(C(=C2N=C1)O)N=NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)S(=O)(=O)O
InChI
InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29)
InChIKey
XGMFVZOKHBRUTL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nsc-87877
CAS: 56990-57-9
CID: 92577
Formula: C19H13N3O7S2
MW: 459.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.5
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass459.01949211
Monoisotopic Mass459.01949211
Topological Polar Surface Area183 Ų
Heavy Atom Count31
Formal Charge0
Complexity883
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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