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NSC 12

CAT: 0013-GTR19240828-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240828-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 12 is an orally bioavailable pan-FGF inhibitor that traps FGF ligands, blocking FGFR1 signaling and disrupting tumor-promoting ternary complex formation without affecting heparin binding. It demonstrates antitumor activity by inhibiting cancer cell proliferation, angiogenesis, and metastasis in both cellular assays and animal models.
CAS Number
102586-30-1
Product Name Alternative
NSC 12, NSC12, NSC-12
Field of Research
Cardiovascular Research, Neuroscience, Signal Transduction
Purity
99.51% (May vary between batches)
Solubility
DMSO:8 mg/mL (16.51 mM) ; Ethanol:PBS (pH 7.2) (1:2) :Insoluble; Ethanol:8 mg/mL (16.51 mM) ; DMF:8 mg/mL (16.51 mM)
Smiles
C[C@@]12[C@] ([C@]3 ([C@@] ([C@]4 (C) C (=CC3) C[C@@H] (O) CC4) (CC1) [H]) [H]) (CC[C@@]2 ([C@H] (CC (C (F) (F) F) (C (F) (F) F) O) O) [H]) [H]
Molecular Formula
C24H34F6O3
Molecular Weight
484.52
Storage Conditions
-20°C
Notes
For research use only.

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