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ICA-27243

CAT: 0013-GTR19174441-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174441-04Size:10 mg
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Description
ICA-27243 is a potent, orally bioavailable opener of KCNQ2/Q3 potassium channels (EC50: 0.38 μM) with demonstrated antiepileptic activity in animal models. It shows reduced efficacy on KCNQ4 and KCNQ3/Q5 channels, making it a selective tool for researching neuronal excitability and neuropathic pain in vitro and in vivo.
CAS Number
325457-89-4
Product Name Alternative
Potassium Channel, PotassiumChannel, KCNQ3, KCNQ2/Q3 potassium channel, KCNQ2, inhibit, Inhibitor, KcsA, opener, hyperpolarization, ICA-27243, ICA27243, ICA 27243, antiepileptic, anticonvulsant
Field of Research
Pharmacology & Drug Discovery
Purity
99.54% (May vary between batches)
Solubility
DMSO:247 mg/mL (919.41 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (12.28 mM)
Smiles
Fc1ccc (cc1F) C (=O) Nc1ccc (Cl) nc1
Molecular Formula
C12H7ClF2N2O
Molecular Weight
268.65
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ica-27243
CAS Number325457-89-4
PubChem CID9903497
IUPAC NameN-(6-chloro-3-pyridinyl)-3,4-difluorobenzamide
Molecular FormulaC12H7ClF2N2O
Molecular Weight268.64
XLogP2.8
Topological Polar Surface Area42
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity306
SMILES
C1=CC(=C(C=C1C(=O)NC2=CN=C(C=C2)Cl)F)F
InChI
InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
InChIKey
GDGUOCFTHNGPBK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ica-27243
CAS: 325457-89-4
CID: 9903497
Formula: C12H7ClF2N2O
MW: 268.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.64
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass268.0214969
Monoisotopic Mass268.0214969
Topological Polar Surface Area42 Ų
Heavy Atom Count18
Formal Charge0
Complexity306
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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