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ICA-27243

CAT: 0013-GTR19174441-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174441-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ICA-27243 is a potent, orally bioavailable opener of KCNQ2/Q3 potassium channels (EC50: 0.38 μM) with demonstrated antiepileptic activity in animal models. It shows reduced efficacy on KCNQ4 and KCNQ3/Q5 channels, making it a selective tool for researching neuronal excitability and neuropathic pain in vitro and in vivo.
CAS Number
325457-89-4
Product Name Alternative
Potassium Channel, PotassiumChannel, KCNQ3, KCNQ2/Q3 potassium channel, KCNQ2, inhibit, Inhibitor, KcsA, opener, hyperpolarization, ICA-27243, ICA27243, ICA 27243, antiepileptic, anticonvulsant
Field of Research
Pharmacology & Drug Discovery
Purity
99.54% (May vary between batches)
Solubility
DMSO:247 mg/mL (919.41 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (12.28 mM)
Smiles
Fc1ccc (cc1F) C (=O) Nc1ccc (Cl) nc1
Molecular Formula
C12H7ClF2N2O
Molecular Weight
268.65
Storage Conditions
-20°C
Notes
For research use only.

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