Products for Research Use Only
RegisterLogin

SMCC-DM1

CAT: 0013-GTR19174160-05Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19174160-05Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SMCC-DM1 is a chemical linker-payload conjugate designed for constructing antibody-drug conjugates (ADCs) . The cytotoxic agent DM1 inhibits microtubule polymerization, while the SMCC linker enables stable attachment to antibodies. This reagent is widely used in preclinical research for developing targeted cancer therapies, with applications in both in vitro cytotoxicity assays and in vivo xenograft models.
CAS Number
1228105-51-8
Product Name Alternative
DM1-SMCC, DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC, Drug-Linker Conjugates for ADC, inhibit, Inhibitor, Maytansinoids, SMCC DM1, SMCCDM1, SMCC-DM1, SMCC-DM-1
Field of Research
Pharmacology & Drug Discovery
Purity
97.07% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.86 mM) ; DMSO:90 mg/mL (83.91 mM)
Smiles
CO[C@@H]1\C=C/C=C (C) \Cc2cc (OC) c (Cl) c (c2) N (C) C (=O) C[C@H] (OC (=O) [C@H] (C) N (C) C (=O) CCSC2CC (=O) N (CC3CCC (CC3) C (=O) ON3C (=O) CCC3=O) C2=O) [C@]2 (C) O[C@H]2[C@H] (C) [C@@H]2C[C@@]1 (O) NC (=O) O2
Molecular Formula
C51H66ClN5O16S
Molecular Weight
1072.61
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

DM1-Smcc
CAS Number1228105-51-8
PubChem CID92131096
IUPAC Name(2,5-dioxopyrrolidin-1-yl) 4-[[3-[3-[[(2S)-1-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy]-1-oxopropan-2-yl]-methylamino]-3-oxopropyl]sulfanyl-2,5-dioxopyrrolidin-1-yl]methyl]cyclohexane-1-carboxylate
Molecular FormulaC51H66ClN5O16S
Molecular Weight1072.6
XLogP2.1
Topological Polar Surface Area283
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count17
Rotatable Bond Count15
Heavy Atom Count74
Formal Charge0
Complexity2250
SMILES
C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCSC5CC(=O)N(C5=O)CC6CCC(CC6)C(=O)ON7C(=O)CCC7=O)C)\C)OC)(NC(=O)O2)O
InChI
InChI=1S/C51H66ClN5O16S/c1-27-10-9-11-37(69-8)51(67)25-35(70-49(66)53-51)28(2)45-50(4,72-45)38(24-42(61)55(6)33-21-31(20-27)22-34(68-7)44(33)52)71-47(64)29(3)54(5)39(58)18-19-74-36-23-43(62)56(46(36)63)26-30-12-14-32(15-13-30)48(65)73-57-40(59)16-17-41(57)60/h9-11,21-22,28-30,32,35-38,45,67H,12-20,23-26H2,1-8H3,(H,53,66)/b11-9+,27-10+/t28-,29+,30?,32?,35+,36?,37-,38+,45+,50+,51+/m1/s1
InChIKey
IADUWZMNTKHTIN-MLSWMBHTSA-N
Chemical Structure
2D Structure
2D structure of DM1-Smcc
CAS: 1228105-51-8
CID: 92131096
Formula: C51H66ClN5O16S
MW: 1072.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data

Related Products

CatalogName
GTR19165789-01SMCC
GTR19253103-01DM1 Impurity
GTR19249009-01SPDB-DM1
GTR19189703-01MC-DM1
GTR19216557-01DM1-SMe
GTR19200351-01DM1-MCC
GTR19189870MCC-DM1
GTR18577580-01DM1 Antibody
GTR19224945-01SPP-DM1
GTR18406314-01DM1 Antibody

Alternative Products

CatalogName
BA2628-1SMCC-DM1
C09009-01DM1-SMCC
A15955-100DM1-SMCC 100mg
BUP00437-01Lys-SMCC-DM1
A15955-200DM1-SMCC 200mg

Popular Products