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SBI-0206965

CAT: 0013-GTR19173618-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173618-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SBI-0206965 is a selective, cell-permeable inhibitor of the autophagy-initiating kinase ULK1, with an IC50 of 108 nM, and also inhibits ULK2 (IC50 = 711 nM) . This tool compound is widely used in vitro and in vivo to investigate the fundamental role of autophagy in cancer, neurodegenerative diseases, and metabolic disorders.
CAS Number
1884220-36-3
Product Name Alternative
Unc-51 like kinase, ULK1, ULK, SBI 0206965, SBI0206965, SBI-0206965, Apoptosis, Autophagy, inhibit, Inhibitor
Field of Research
Cell Biology
Purity
>98%
Bioactivity
ULK1 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml)
Smiles
CNC (=O) c1ccccc1Oc1nc (Nc2cc (OC) c (OC) c (OC) c2) ncc1Br
Molecular Formula
C21H21BrN4O5
Molecular Weight
489.32
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2- ((5-Bromo-2- ((3,4,5-trimethoxyphenyl) amino) pyrimidin-4-yl) oxy) -N-methylbenzamide

Chemical Information

Sbi-0206965

inhibits ULK1 kinase; structure in first source

CAS Number1884220-36-3
PubChem CID92044402
IUPAC Name2-[5-bromo-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]oxy-N-methylbenzamide
Molecular FormulaC21H21BrN4O5
Molecular Weight489.3
XLogP3.8
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity560
SMILES
CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC
InChI
InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
InChIKey
NEXGBSJERNQRSV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sbi-0206965
CAS: 1884220-36-3
CID: 92044402
Formula: C21H21BrN4O5
MW: 489.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight489.3
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count8
Exact Mass488.06953
Monoisotopic Mass488.06953
Topological Polar Surface Area104 Ų
Heavy Atom Count31
Formal Charge0
Complexity560
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
CST 29089SSBI-0206965

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