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Chloroquine-d5

CAT: 0804-HY-17589AS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17589AS-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Chloroquine-d5 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[2][3][4].
CAS Number
1854126-41-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; HIV; Isotope-Labeled Compounds; Parasite; SARS-CoV; Toll-like Receptor (TLR)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.90
Solubility
10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)C([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C18H21D5ClN3
Molecular Weight
324.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193 (12) :6135-43.|[2]Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6 (6) :1665-1672.|[3]Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.|[4]Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55 (4) :105932.|[5]Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20 (3) :131-135.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
HIV-1; Plasmodium

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CS-O-47498Chloroquine d5
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AR-C07181-01Chloroquine-d5 Diphosphate
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AR-C02467-01Desethyl Chloroquine-d5 HCl
AR-C07179-01N-Nitroso Chloroquine-d5
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