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Blebbistatin

CAT: 0013-GTR19174157-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174157-01Size:5 mg
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Description
Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII) and MYH9. It promotes directional migration and accelerates wound healing in corneal endothelial cells in vitro, while preserving cell junction integrity and barrier function. This small molecule is widely used in cytoskeleton and cell migration research.
CAS Number
674289-55-5
Product Name Alternative
Blebbistatin, (±) -Blebbistatin, Myosin, non-muscle myosin II ATPases, inhibit, Inhibitor
Field of Research
Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (up to45 mg/ml)
Smiles
Cc1ccc2N=C3N (CCC3 (O) C (=O) c2c1) c1ccccc1
Molecular Formula
C18H16N2O2
Molecular Weight
292.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one, (+/-)

Chemical Information

1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo(2,3-b)quinolin-4-one

Blebbistatin is a pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II. It has a role as an inhibitor. It is a tertiary alpha-hydroxy ketone, a tertiary alcohol, a cyclic ketone and a pyrroloquinoline.

CAS Number674289-55-5
PubChem CID3476986
IUPAC Name3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
Molecular FormulaC18H16N2O2
Molecular Weight292.3
XLogP2.4
Topological Polar Surface Area52.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity497
SMILES
CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
InChI
InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
InChIKey
LZAXPYOBKSJSEX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo(2,3-b)quinolin-4-one
CAS: 674289-55-5
CID: 3476986
Formula: C18H16N2O2
MW: 292.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.3
XLogP32.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass292.121177757
Monoisotopic Mass292.121177757
Topological Polar Surface Area52.9 Ų
Heavy Atom Count22
Formal Charge0
Complexity497
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T6038-01(-) -Blebbistatin
2406-1(-)-Blebbistatin
2405-5(±)-Blebbistatin
2407-5(+)-Blebbistatin
MBS3614304-01Blebbistatin
BML-EI315-0025Blebbistatin (+/-)
sc-203532D(±) -Blebbistatin
BUP09824-01(+) -Blebbistatin
FB18838-01(+/-) -Blebbistatin

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