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Nutlin-3

CAT: 0013-GTR19174046-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174046-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nutlin-3 is a potent and selective MDM2 antagonist (Ki=90 nM) that stabilizes p53 by blocking its interaction with MDM2. This activation of the p53 pathway confers observed antitumor activity, making it a valuable tool for cancer research in both cellular and animal models.
CAS Number
548472-68-0
Product Name Alternative
E2 Enzyme, E2 conjugating enzyme, E2Enzyme, E3 Enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E3 ligating enzyme, E3Enzyme, Nutlin 3, Nutlin3, Nutlin-3, inhibit, p53-MDM2, MDM-2/p53, Inhibitor, Ubiquitin ligase, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme
Field of Research
Cell Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
P53/mdm2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml) .
Smiles
COc1ccc (C2=NC (C (N2C (=O) N2CCNC (=O) C2) c2ccc (Cl) cc2) c2ccc (Cl) cc2) c (OC (C) C) c1
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.51
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(±) -4-[4,5-Bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

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