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Nutlin-3

CAT: 0013-GTR19174046-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174046-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nutlin-3 is a potent and selective MDM2 antagonist (Ki=90 nM) that stabilizes p53 by blocking its interaction with MDM2. This activation of the p53 pathway confers observed antitumor activity, making it a valuable tool for cancer research in both cellular and animal models.
CAS Number
548472-68-0
Product Name Alternative
E2 Enzyme, E2 conjugating enzyme, E2Enzyme, E3 Enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, E3 ligating enzyme, E3Enzyme, Nutlin 3, Nutlin3, Nutlin-3, inhibit, p53-MDM2, MDM-2/p53, Inhibitor, Ubiquitin ligase, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme
Field of Research
Cell Biology, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
P53/mdm2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml) .
Smiles
COc1ccc (C2=NC (C (N2C (=O) N2CCNC (=O) C2) c2ccc (Cl) cc2) c2ccc (Cl) cc2) c (OC (C) C) c1
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.51
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
(±) -4-[4,5-Bis (4-chlorophenyl) -2- (2-isopropoxy-4-methoxy-phenyl) -4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

Chemical Information

Nutlin 3

4-[[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.

CAS Number548472-68-0
PubChem CID11433190
IUPAC Name4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
Molecular FormulaC30H30Cl2N4O4
Molecular Weight581.5
XLogP5.2
Topological Polar Surface Area83.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count40
Formal Charge0
Complexity919
SMILES
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
InChIKey
BDUHCSBCVGXTJM-WUFINQPMSA-N
Chemical Structure
2D Structure
2D structure of Nutlin 3
CAS: 548472-68-0
CID: 11433190
Formula: C30H30Cl2N4O4
MW: 581.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight581.5
XLogP35.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass580.1644108
Monoisotopic Mass580.1644108
Topological Polar Surface Area83.5 Ų
Heavy Atom Count40
Formal Charge0
Complexity919
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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