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CNX-1351

CAT: 0013-GTR19172668-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172668-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CNX-1351 is a covalent small molecule inhibitor that selectively targets the PI3Kα isoform. It is a valuable research tool for investigating PI3Kα-driven signaling pathways in oncology, applicable in both cellular and animal models of cancer.
CAS Number
1276105-89-5
Product Name Alternative
Inhibit, Inhibitor, CNX 1351, CNX1351, CNX-1351, Phosphoinositide 3-kinase, PI3K, PI3Kα
Field of Research
Cell Biology, Signal Transduction
Purity
98.83% (May vary between batches)
Solubility
DMSO:5.74 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.74 mM)
Smiles
CC (C) =CC (=O) CCC (=O) N1CCN (Cc2cc3nc (nc (N4CCOCC4) c3s2) -c2cccc3[nH]ncc23) CC1
Molecular Formula
C30H35N7O3S
Molecular Weight
573.71
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(4-{[2-(1H-indazol-4-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
CAS Number1276105-89-5
PubChem CID58441401
IUPAC Name1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methylhept-5-ene-1,4-dione
Molecular FormulaC30H35N7O3S
Molecular Weight573.7
XLogP2.9
Topological Polar Surface Area136
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Heavy Atom Count41
Formal Charge0
Complexity950
SMILES
CC(=CC(=O)CCC(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6)C
InChI
InChI=1S/C30H35N7O3S/c1-20(2)16-21(38)6-7-27(39)36-10-8-35(9-11-36)19-22-17-26-28(41-22)30(37-12-14-40-15-13-37)33-29(32-26)23-4-3-5-25-24(23)18-31-34-25/h3-5,16-18H,6-15,19H2,1-2H3,(H,31,34)
InChIKey
DLNUPKDFXMWRFP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-{[2-(1H-indazol-4-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
CAS: 1276105-89-5
CID: 58441401
Formula: C30H35N7O3S
MW: 573.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight573.7
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count8
Exact Mass573.25220918
Monoisotopic Mass573.25220918
Topological Polar Surface Area136 Ų
Heavy Atom Count41
Formal Charge0
Complexity950
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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