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SNS-032

CAT: 0013-GTR19171794-08Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171794-08Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNS-032 is a potent and selective cyclin-dependent kinase inhibitor, primarily targeting CDK2 (IC50=48 nM), CDK7, and CDK9, with weaker activity against CDK1 and CDK4. It has been utilized in cancer research to study transcriptional regulation and cell cycle arrest in various in vitro and in vivo models.
CAS Number
345627-80-7
Product Name Alternative
BMS 387032, BMS387032, BMS-387032, Apoptosis, Cyclin dependent kinase, CDK, CDK2/CyclinA, CDK2/CyclinE, CDK9/CyclinT, CDK7/CyclinH, inhibit, GSK3, GSK-3α, Inhibitor, SNS032, SNS-032, SNS 032
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.27% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM) ; DMSO:64.38 mg/mL (169.19 mM)
Smiles
C (SC=1SC (NC (=O) C2CCNCC2) =NC1) C=3OC (C (C) (C) C) =CN3
Molecular Formula
C17H24N4O2S2
Molecular Weight
380.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide

N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a secondary carboxamide, an organic sulfide, a member of 1,3-thiazoles, a member of 1,3-oxazoles and a piperidinecarboxamide.

CAS Number345627-80-7
PubChem CID3025986
IUPAC NameN-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
Molecular FormulaC17H24N4O2S2
Molecular Weight380.5
XLogP3
Topological Polar Surface Area134
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity454
SMILES
CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
InChI
InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
InChIKey
OUSFTKFNBAZUKL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(5-(((5-(1,1-Dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide
CAS: 345627-80-7
CID: 3025986
Formula: C17H24N4O2S2
MW: 380.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.5
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass380.13406837
Monoisotopic Mass380.13406837
Topological Polar Surface Area134 Ų
Heavy Atom Count25
Formal Charge0
Complexity454
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
FS16408-01SNS 032
HY-10008-01SNS-032
HY-10008R-01SNS-032 (Standard)
T17069-01THAL-SNS-032

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