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SNS-314

CAT: 0013-GTR19163586-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163586-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively; demonstrates broad activity in vitro against multiple human cancer cell lines and exhibits significant in vivo activity against a wide range of tumor xenograft models; shows additive antiproliferative effects with carboplatin, gemcitabine, 5-FU, daunomycin, and SN-38 both in vitro and in vivo.Solid Tumors Phase 1 Discontinued (In Vitro) :SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells. (In Vivo) :In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off.
CAS Number
1146618-41-8
Product Name Alternative
SNS-314 Mesylate | SNS314 | SNS 314
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CS (=O) (=O) O.C1=CC (=CC (=C1) Cl) NC (=O) NC2=NC=C (S2) CCNC3=NC=NC4=C3SC=C4
Molecular Formula
C19H19ClN6O4S3
Molecular Weight
527.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N- (3-chlorophenyl) -N'-[5-[2- (thieno[3,2-d]pyrimidin-4-ylamino) ethyl]-2-thiazolyl]-, methanesulfonate (1:1)

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CatalogName
BA3718-5.1SNS-314

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