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SNS-314

CAT: 0013-GTR19163586-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163586-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNS-314 is a potent, selective pan-Aurora kinase inhibitor with IC50 of 9 and 31 nM for Aurora A and Aurora B, repectively; demonstrates broad activity in vitro against multiple human cancer cell lines and exhibits significant in vivo activity against a wide range of tumor xenograft models; shows additive antiproliferative effects with carboplatin, gemcitabine, 5-FU, daunomycin, and SN-38 both in vitro and in vivo.Solid Tumors Phase 1 Discontinued (In Vitro) :SNS-314 blocks proliferation in a broad panel of tumor cell lines (HCT116, A2780, PC-3, HeLa, MDA-MB-231, H-1299, and HT29) with IC50 values ranging from 1.8 nM in A2780 ovarian cancer cells to 24 nM in HT29 colon cancer cells. (In Vivo) :In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off.
CAS Number
1146618-41-8
Product Name Alternative
SNS-314 Mesylate | SNS314 | SNS 314
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CS (=O) (=O) O.C1=CC (=CC (=C1) Cl) NC (=O) NC2=NC=C (S2) CCNC3=NC=NC4=C3SC=C4
Molecular Formula
C19H19ClN6O4S3
Molecular Weight
527.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N- (3-chlorophenyl) -N'-[5-[2- (thieno[3,2-d]pyrimidin-4-ylamino) ethyl]-2-thiazolyl]-, methanesulfonate (1:1)

Chemical Information

SNS-314 Mesylate
CAS Number1146618-41-8
PubChem CID24995523
IUPAC Name1-(3-chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea;methanesulfonic acid
Molecular FormulaC19H19ClN6O4S3
Molecular Weight527.0
Topological Polar Surface Area211
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count33
Formal Charge0
Complexity625
SMILES
CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
InChI
InChI=1S/C18H15ClN6OS2.CH4O3S/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16;1-5(2,3)4/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26);1H3,(H,2,3,4)
InChIKey
FYCODPVDEFFWSR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SNS-314 Mesylate
CAS: 1146618-41-8
CID: 24995523
Formula: C19H19ClN6O4S3
MW: 527.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight527.0
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass526.0318443
Monoisotopic Mass526.0318443
Topological Polar Surface Area211 Ų
Heavy Atom Count33
Formal Charge0
Complexity625
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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