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Jolkinolide B

CAT: 0013-GTR19171173-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19171173-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Jolkinolide B is a bioactive diterpenoid isolated from Euphorbia fischeriana roots, known for inducing apoptosis in various cancer cell lines. Its application extends to research on osteolysis prevention, with studies demonstrating efficacy in both in vitro cellular models and in vivo bone resorption assays.
CAS Number
37905-08-1
Product Name Alternative
Inhibit, JAK, JNK, Jolkinolide B, ILReceptor, mTOR, NF-κB, NFκB, NF-kB, NFkB, leukemic, IL Receptor, Inhibitor, ERK, human, cells, Caspase, Bcl-2, cancer, Apoptosis, Akt, STAT, TNF-α, p38MAPK, p38 MAPK, PI3K, U937
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.39% (May vary between batches)
Solubility
DMSO:3.31 mg/mL (10.02 mM)
Smiles
[H][C@]12CC[C@@]34O[C@@H]3C3=C (C) C (=O) O[C@]33O[C@@H]3[C@@]4 ([H]) [C@]1 (C) CCCC2 (C) C
Molecular Formula
C20H26O4
Molecular Weight
330.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Jolkinolide B

Jolkinolide B is a diterpene lactone. It has a role as a metabolite.

CAS Number37905-08-1
PubChem CID161954
IUPAC Name(1S,3R,8R,10R,11R,12R,17R)-5,12,16,16-tetramethyl-2,7,9-trioxahexacyclo[9.8.0.01,3.04,8.08,10.012,17]nonadec-4-en-6-one
Molecular FormulaC20H26O4
Molecular Weight330.4
XLogP3.2
Topological Polar Surface Area51.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Heavy Atom Count24
Formal Charge0
Complexity723
SMILES
CC1=C2[C@@H]3[C@]4(O3)CC[C@H]5[C@]([C@@H]4[C@@H]6[C@]2(O6)OC1=O)(CCCC5(C)C)C
InChI
InChI=1S/C20H26O4/c1-10-12-14-19(22-14)9-6-11-17(2,3)7-5-8-18(11,4)13(19)15-20(12,23-15)24-16(10)21/h11,13-15H,5-9H2,1-4H3/t11-,13+,14-,15-,18-,19+,20-/m1/s1
InChIKey
SOVOCMGDFRGRKF-MCDHERAVSA-N
Chemical Structure
2D Structure
2D structure of Jolkinolide B
CAS: 37905-08-1
CID: 161954
Formula: C20H26O4
MW: 330.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight330.4
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass330.18310931
Monoisotopic Mass330.18310931
Topological Polar Surface Area51.4 Ų
Heavy Atom Count24
Formal Charge0
Complexity723
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
TN4356Jolkinolide A
N2756-20Jolkinolide B
ECA49434-01Jolkinolide E
A14640-50Jolkinolide B 50mg
A14640-5Jolkinolide B 5mg
A14640-1Jolkinolide B 1mg
HY-N0732RJolkinolide B (Standard)
A14640-25Jolkinolide B 25mg
A14640-10Jolkinolide B 10mg

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