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RA375

CAT: 0013-GTR19170977-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170977-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RA375 is a potent small molecule inhibitor of the proteasome regulatory subunit RPN13, exhibiting enhanced pro-apoptotic activity through UPR activation and ROS induction. Its superior cytotoxicity, attributed to a nitroaryl group and chloroacetamide warhead, makes it a valuable chemical probe for studying proteasome biology and cancer cell death mechanisms in vitro.
CAS Number
2649154-57-2
Product Name Alternative
RA 375, RA375, RA-375, 26S proteasome
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction
Purity
99.35% (May vary between batches)
Solubility
DMSO:125 mg/mL (212.23 mM)
Smiles
O=C (CCl) N[C@H] (C (N1C/C (C (/C (C1) =C/C2=CC=C ([N+] ([O-]) =O) C=C2) =O) =C\C3=CC=C ([N+] ([O-]) =O) C=C3) =O) CC4=CC=CC=C4
Molecular Formula
C30H25ClN4O7
Molecular Weight
588.99
Storage Conditions
-20°C
Notes
For research use only.

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