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RA375

CAT: 0013-GTR19170977-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170977-01Size:2 mg
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Description
RA375 is a potent small molecule inhibitor of the proteasome regulatory subunit RPN13, exhibiting enhanced pro-apoptotic activity through UPR activation and ROS induction. Its superior cytotoxicity, attributed to a nitroaryl group and chloroacetamide warhead, makes it a valuable chemical probe for studying proteasome biology and cancer cell death mechanisms in vitro.
CAS Number
2649154-57-2
Product Name Alternative
RA 375, RA375, RA-375, 26S proteasome
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Protein Biochemistry, Signal Transduction
Purity
99.35% (May vary between batches)
Solubility
DMSO:125 mg/mL (212.23 mM)
Smiles
O=C (CCl) N[C@H] (C (N1C/C (C (/C (C1) =C/C2=CC=C ([N+] ([O-]) =O) C=C2) =O) =C\C3=CC=C ([N+] ([O-]) =O) C=C3) =O) CC4=CC=CC=C4
Molecular Formula
C30H25ClN4O7
Molecular Weight
588.99
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 146681207
CAS Number2649154-57-2
PubChem CID146681207
IUPAC NameN-[(2S)-1-[(3E,5E)-3,5-bis[(4-nitrophenyl)methylidene]-4-oxopiperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]-2-chloroacetamide
Molecular FormulaC30H25ClN4O7
Molecular Weight589.0
XLogP4.7
Topological Polar Surface Area158
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count42
Formal Charge0
Complexity1020
SMILES
C\1N(C/C(=C\C2=CC=C(C=C2)[N+](=O)[O-])/C(=O)/C1=C/C3=CC=C(C=C3)[N+](=O)[O-])C(=O)[C@@H](NC(=O)CCl)CC4=CC=CC=C4
InChI
InChI=1S/C30H25ClN4O7/c31-17-28(36)32-27(16-20-4-2-1-3-5-20)30(38)33-18-23(14-21-6-10-25(11-7-21)34(39)40)29(37)24(19-33)15-22-8-12-26(13-9-22)35(41)42/h1-15,27H,16-19H2,(H,32,36)/b23-14+,24-15+/t27-/m0/s1
InChIKey
REFAVUFYPFWJGH-SWAPHQFDSA-N
Chemical Structure
2D Structure
2D structure of CID 146681207
CAS: 2649154-57-2
CID: 146681207
Formula: C30H25ClN4O7
MW: 589.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight589.0
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass588.1411768
Monoisotopic Mass588.1411768
Topological Polar Surface Area158 Ų
Heavy Atom Count42
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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