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RA375

CAT: 0931-T36902-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T36902-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2649154-57-2
Target
ROS, Reactive Oxygen Species, Apoptosis, Proteasome
Related Pathways
Immunology/Inflammation, NF-κB, Proteases/Proteasome, Metabolism, Apoptosis, Ubiquitination
Purity
0.9956
Bioactivity
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
Smiles
O=C(CCl)N[C@H](C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4
Molecular Formula
C30H25ClN4O7
Molecular Weight
588.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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