Specnuezhenide

CAT: 0013-GTR19170810-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19170810-01Size:2 mg

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Description

Specnuezhenide (Nuezhenide) is a natural compound derived from Ligustrum lucidum fruit. It demonstrates anti-inflammatory activity by inhibiting NF-κB and Wnt/β-catenin signaling pathways, as shown in IL-1β-stimulated chondrocyte studies. This mechanism underlies its protective effects observed in rat models of osteoarthritis.

CAS Number

39011-92-2

Product Name Alternative

Inhibit, Inhibitor, Nuclear factor-kappaB, Nuclear factor-κB, Nuzhenide, Nuezhenide, NF-κB, NF-kB, NFkB, NFκB, bcatenin, anti-angiogenic, (8E) -Nuezhenide, diabetic retinopathy, betacatenin, beta-catenin, βcatenin, Wnt/β-catenin, Wnt/b-catenin, Wnt, Wnt/betacatenin, osteoarthritis, Specnuezhenide

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Purity

98.00% (May vary between batches)

Solubility

DMSO:137.5 mg/mL (200.24 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.28 mM)

Smiles

COC (=O) C1=CO[C@@H] (O[C@@H]2O[C@H] (CO) [C@@H] (O) [C@H] (O) [C@H]2O) \C (=C\C) [C@@H]1CC (=O) OC[C@H]1O[C@@H] (OCCc2ccc (O) cc2) [C@H] (O) [C@@H] (O) [C@@H]1O

Molecular Formula

C31H42O17

Molecular Weight

686.66

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Nuezhenide

Nuezhenide is natural product found in Fraxinus angustifolia, Syringa vulgaris, and other organisms.

CAS Number	39011-92-2
PubChem CID	6440999
IUPAC Name	methyl (5E,6S)-5-ethylidene-4-[2-oxo-2-[[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy]ethyl]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate
Molecular Formula	C31H42O17
Molecular Weight	686.7
XLogP	-2.2
Topological Polar Surface Area	261
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	14
Heavy Atom Count	48
Formal Charge	0
Complexity	1120

SMILES

C/C=C\1/[C@@H](OC=C(C1CC(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OCCC3=CC=C(C=C3)O)O)O)O)C(=O)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O

InChI

InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3+/t17?,19-,20-,22-,23-,24+,25+,26-,27-,29+,30-,31+/m1/s1

InChIKey

STKUCSFEBXPTAY-YTECAPLWSA-N

Chemical Structure

2D Structure

CAS: 39011-92-2

CID: 6440999

Formula: C31H42O17

MW: 686.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	686.7
XLogP3	-2.2
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	17
Rotatable Bond Count	14
Exact Mass	686.24219987
Monoisotopic Mass	686.24219987
Topological Polar Surface Area	261 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	1120
Isotope Atom Count	0
Defined Atom Stereocenter Count	11
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

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GTR19169791-01	Specneuzhenide
GTR19157868-01	Specneuzhenide

Alternative Products

Catalog	Name
T3803-01	Specnuezhenide
A14695-10	Specnuezhenide 10mg
A14695-5	Specnuezhenide 5mg
A14695-500	Specnuezhenide 500mg
A14695-25	Specnuezhenide 25mg
A14695-2	Specnuezhenide 2mg
A14695-1	Specnuezhenide 1mg
HY-N0665R	Specnuezhenide (Standard)
A14695-100	Specnuezhenide 100mg
A14695-50	Specnuezhenide 50mg

Specnuezhenide

Chemical Information

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