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Specnuezhenide

CAT: 0804-HY-N0665-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0665-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Specnuezhenide ((8E) -Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E) -Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E) -Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) [1].
CAS Number
39011-92-2
Product Name Alternative
(8E) -Nuezhenide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; Wnt
Type
Natural Products
Related Pathways
NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/specnuezhenide.html
Purity
99.52
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C/C=C([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)\[C@@H](C(C(OC)=O)=CO1)CC(OC[C@H]([C@H]([C@H](O)[C@H]3O)O)O[C@H]3OCCC4=CC=C(O)C=C4)=O
Molecular Formula
C31H42O17
Molecular Weight
686.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.|[2]Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21 (12) . pii: E1756.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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