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NMS-859

CAT: 0013-GTR19176554-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176554-07Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NMS-859 is a potent, covalent inhibitor of VCP/p97, demonstrating consistent cellular activity with IC50 values of approximately 0.37 μM across physiological ATP concentrations. This small molecule is a valuable research tool for investigating VCP-related pathways in cancer, neurodegenerative diseases, and in vitro protein homeostasis studies.
CAS Number
1449236-96-7
Product Name Alternative
Valosin-containing protein (VCP) /p97, ZINC 169324353, ZINC169324353, ZINC-169324353, NMS 859, NMS859, NMS-859
Field of Research
Neuroscience, Protein Biochemistry
Purity
97.36% (May vary between batches)
Solubility
DMSO:3.5 mg/mL (10.01 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.86 mM)
Smiles
ClCC (=O) OC1=CC=CC (NC2=NS (=O) (=O) C3=C2C=CC=C3) =C1
Molecular Formula
C15H12ClN3O3S
Molecular Weight
349.79
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
CAS Number1449236-96-7
PubChem CID71607189
IUPAC Name2-chloro-N-[3-[(1,1-dioxo-1,2-benzothiazol-3-yl)amino]phenyl]acetamide
Molecular FormulaC15H12ClN3O3S
Molecular Weight349.8
XLogP1.8
Topological Polar Surface Area96
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity587
SMILES
C1=CC=C2C(=C1)C(=NS2(=O)=O)NC3=CC(=CC=C3)NC(=O)CCl
InChI
InChI=1S/C15H12ClN3O3S/c16-9-14(20)17-10-4-3-5-11(8-10)18-15-12-6-1-2-7-13(12)23(21,22)19-15/h1-8H,9H2,(H,17,20)(H,18,19)
InChIKey
JWMFLBAPPIWNGG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-chloro-N-(3-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)phenyl)acetamide
CAS: 1449236-96-7
CID: 71607189
Formula: C15H12ClN3O3S
MW: 349.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.8
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass349.0287901
Monoisotopic Mass349.0287901
Topological Polar Surface Area96 Ų
Heavy Atom Count23
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS3846388-01NMS-859
A21965-100NMS-859 100mg
A21965-1NMS-859 1mg
A21965-500NMS-859 500mg
A21965-25NMS-859 25mg
A21965-10NMS-859 10mg
A21965-5NMS-859 5mg
A21965-50NMS-859 50mg
A21965-2NMS-859 2mg
bs-60148C-01NMS-859 --- ATPase VCP/p97 Inhibitor

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