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BMS-794833

CAT: 0013-GTR19174899-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174899-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-794833 is an ATP-competitive small molecule inhibitor targeting Met and VEGFR2 kinases. It serves as a prodrug for the active metabolite BMS-817378. This compound is utilized in cancer research for investigating angiogenesis and tumor growth in both cellular and animal models.
CAS Number
1174046-72-0
Product Name Alternative
Vascular endothelial growth factor receptor, VEGFR, VEGFR2, inhibit, Met, Inhibitor, HGFR, BMS 794833, BMS794833, BMS-794833, c-Met, cMet, c-Met/HGFR, cMet/HGFR
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
DMSO:117.5 mg/mL (250.62 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.04 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Nc1nccc (Oc2ccc (NC (=O) c3c[nH]cc (-c4ccc (F) cc4) c3=O) cc2F) c1Cl
Molecular Formula
C23H15ClF2N4O3
Molecular Weight
468.84
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
CAS Number1174046-72-0
PubChem CID44155856
IUPAC NameN-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide
Molecular FormulaC23H15ClF2N4O3
Molecular Weight468.8
XLogP3.8
Topological Polar Surface Area106
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity803
SMILES
C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F
InChI
InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32)
InChIKey
PDYXPCKITKHFOZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
CAS: 1174046-72-0
CID: 44155856
Formula: C23H15ClF2N4O3
MW: 468.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.8
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass468.0800744
Monoisotopic Mass468.0800744
Topological Polar Surface Area106 Ų
Heavy Atom Count33
Formal Charge0
Complexity803
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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B1438-5.1BMS-794833
WGC308005-5mgBMS 794833

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