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Dacinostat

CAT: 0013-GTR19174849-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174849-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LAQ824 (Dacinostat) is a potent histone deacetylase (HDAC) inhibitor with an IC50 of 32 nM. It activates the p21 promoter and has demonstrated anti-proliferative activity in various cancer cell lines in vitro, supporting its investigation in oncology research.
CAS Number
404951-53-7
Product Name Alternative
Dacinostat, Autophagy, NVP-LAQ 824, NVP-LAQ824, NVP-LAQ-824, inhibit, HDAC, Inhibitor, Histone deacetylases, LAQ 824, LAQ824, LAQ-824
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
95.28% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:245 mg/mL (645.67 mM)
Smiles
OCCN (CCc1c[nH]c2ccccc12) Cc1ccc (\C=C\C (=O) NO) cc1
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Dacinostat

N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide is a member of tryptamines.

CAS Number404951-53-7
PubChem CID6445533
IUPAC Name(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide
Molecular FormulaC22H25N3O3
Molecular Weight379.5
XLogP2.6
Topological Polar Surface Area88.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count28
Formal Charge0
Complexity505
SMILES
C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO
InChI
InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+
InChIKey
BWDQBBCUWLSASG-MDZDMXLPSA-N
Chemical Structure
2D Structure
2D structure of Dacinostat
CAS: 404951-53-7
CID: 6445533
Formula: C22H25N3O3
MW: 379.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.5
XLogP32.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass379.18959167
Monoisotopic Mass379.18959167
Topological Polar Surface Area88.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity505
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
200845Dacinostat
S1095-1gDacinostat (LAQ824)
HY-13606R-01Dacinostat (Standard)
MBS576322LAQ824 (Dacinostat)
HY-116619(E/Z) -Dacinostat
A4103-5.1LAQ824 (NVP-LAQ824,Dacinostat)
MBS385847-01LAQ824 (NVP-LAQ824, Dacinostat)

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