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TRPC6-PAM-C20

CAT: 0013-GTR19170900-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170900-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRPC6-PAM-C20 is a selective positive allosteric modulator of the TRPC6 ion channel. It potentiates OAG-induced platelet aggregation and elevates intracellular calcium in TRPC6-expressing HEK cells with an EC50 of 2.37 μM. This compound is a valuable research tool for studying TRPC6 function in cardiovascular and renal systems in vitro.
CAS Number
667427-75-0
Product Name Alternative
3- (6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl) -chromen-2-one, TRPVChannel, TRPV Channel, TRPChannel, TRPC6, TRPC6-PAM-C20, TRP Channel
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
90.00% (May vary between batches)
Solubility
DMSO:90 mg/mL (247.65 mM)
Smiles
COc1cc2CC (C) (C) N=C (c2cc1OC) c1cc2ccccc2oc1=O
Molecular Formula
C22H21NO4
Molecular Weight
363.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Trpc6-pam-C20
CAS Number667427-75-0
PubChem CID1081484
IUPAC Name3-(6,7-dimethoxy-3,3-dimethyl-4H-isoquinolin-1-yl)chromen-2-one
Molecular FormulaC22H21NO4
Molecular Weight363.4
XLogP4
Topological Polar Surface Area57.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity653
SMILES
CC1(CC2=CC(=C(C=C2C(=N1)C3=CC4=CC=CC=C4OC3=O)OC)OC)C
InChI
InChI=1S/C22H21NO4/c1-22(2)12-14-10-18(25-3)19(26-4)11-15(14)20(23-22)16-9-13-7-5-6-8-17(13)27-21(16)24/h5-11H,12H2,1-4H3
InChIKey
SNICUMZYPOCXCO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trpc6-pam-C20
CAS: 667427-75-0
CID: 1081484
Formula: C22H21NO4
MW: 363.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight363.4
XLogP34
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass363.14705815
Monoisotopic Mass363.14705815
Topological Polar Surface Area57.1 Ų
Heavy Atom Count27
Formal Charge0
Complexity653
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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