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Pitstop 2

CAT: 0013-GTR19173651-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173651-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pitstop 2 is a selective, amphipathic small molecule inhibitor of the clathrin terminal domain (IC50=12 μM) . It potently blocks clathrin-mediated processes including receptor endocytosis, viral entry, and synaptic vesicle recycling, and exhibits antitumor activity in research models.
CAS Number
1419320-73-2
Product Name Alternative
CME, clathrin, clathrin-mediated, cancer, Apoptosis, endocytosis, Inhibitor, inhibit, Pitstop 2, Pitstop2, Pitstop-2
Field of Research
Cell Biology
Purity
99.53% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.23 mM) ; DMSO:22 mg/mL (46.48 mM)
Smiles
S (NC=1S/C (=C\C2=CC=C (Br) C=C2) /C (=O) N1) (=O) (=O) C=3C4=C (C=CC3) C=CC=C4
Molecular Formula
C20H13BrN2O3S2
Molecular Weight
473.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(5-(4-Bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide
CAS Number1419320-73-2
PubChem CID137254289
IUPAC NameN-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide
Molecular FormulaC20H13BrN2O3S2
Molecular Weight473.4
XLogP5.5
Topological Polar Surface Area109
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity767
SMILES
C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)/C(=C/C4=CC=C(C=C4)Br)/S3
InChI
InChI=1S/C20H13BrN2O3S2/c21-15-10-8-13(9-11-15)12-17-19(24)22-20(27-17)23-28(25,26)18-7-3-5-14-4-1-2-6-16(14)18/h1-12H,(H,22,23,24)/b17-12-
InChIKey
CGDLWHGPJPVPDU-ATVHPVEESA-N
Chemical Structure
2D Structure
2D structure of N-(5-(4-Bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide
CAS: 1419320-73-2
CID: 137254289
Formula: C20H13BrN2O3S2
MW: 473.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight473.4
XLogP35.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass471.95510
Monoisotopic Mass471.95510
Topological Polar Surface Area109 Ų
Heavy Atom Count28
Formal Charge0
Complexity767
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A22252-50Pitstop 2 50mg

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