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AZD4635

CAT: 0013-GTR19170383-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19170383-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD4635 (HTL1071) is a potent and selective adenosine A2A receptor antagonist with a Ki of 1.7 nM. It is a valuable research tool for investigating adenosine signaling in immuno-oncology, with demonstrated activity in both in vitro cellular assays and in vivo tumor models.
CAS Number
1321514-06-0
Product Name Alternative
P1 receptor, AdenosineReceptor, Adenosine Receptor, A2A, AZD 4635, AZD4635, AZD-4635, inhibit, Imaradenant, HTL 1071, HTL1071, HTL-1071, Inhibitor
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.07% (May vary between batches)
Solubility
H2O:< 0.1 mg/mL (insoluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.45 mM) ; DMSO:83.3 mg/mL (263.83 mM)
Smiles
Cc1cc (cc (Cl) n1) -c1nnc (N) nc1-c1ccc (F) cc1
Molecular Formula
C15H11ClFN5
Molecular Weight
315.73
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Imaradenant

Imaradenant is under investigation in clinical trial NCT03381274 (Oleclumab (MEDI9447) Egfrm NSCLC Novel Combination Study).

CAS Number1321514-06-0
PubChem CID86676119
IUPAC Name6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
Molecular FormulaC15H11ClFN5
Molecular Weight315.73
XLogP2.6
Topological Polar Surface Area77.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity366
SMILES
CC1=CC(=CC(=N1)Cl)C2=C(N=C(N=N2)N)C3=CC=C(C=C3)F
InChI
InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
InChIKey
NCWQLHHDGDXIJN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Imaradenant
CAS: 1321514-06-0
CID: 86676119
Formula: C15H11ClFN5
MW: 315.73
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight315.73
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass315.0687012
Monoisotopic Mass315.0687012
Topological Polar Surface Area77.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity366
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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