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SS-Lapachone

CAT: 0013-GTR19169959-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19169959-01Size:5 mg
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Description
β-Lapachone (ARQ-501) is a selective inhibitor of DNA topoisomerase I, exhibiting no activity against topoisomerase II or DNA ligase. This compound is utilized in cancer research, demonstrating antitumor effects in both cellular studies and animal models.
CAS Number
4707-32-8
Product Name Alternative
NSC 26326
Field of Research
Cell Biology
Purity
>98%
Bioactivity
Topoisomerase I inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Smiles
CC1 (C) CCC2=C (O1) c1ccccc1C (=O) C2=O
Molecular Formula
C15H14O3
Molecular Weight
242.27
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione

Chemical Information

Beta-Lapachone

Beta-lapachone is a benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities. It has a role as an antineoplastic agent, an anti-inflammatory agent and a plant metabolite. It is a member of orthoquinones and a benzochromenone.

CAS Number4707-32-8
PubChem CID3885
IUPAC Name2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
Molecular FormulaC15H14O3
Molecular Weight242.27
XLogP2.2
Topological Polar Surface Area43.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity445
SMILES
CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
InChI
InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
InChIKey
QZPQTZZNNJUOLS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Beta-Lapachone
CAS: 4707-32-8
CID: 3885
Formula: C15H14O3
MW: 242.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight242.27
XLogP32.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass242.094294304
Monoisotopic Mass242.094294304
Topological Polar Surface Area43.4 Ų
Heavy Atom Count18
Formal Charge0
Complexity445
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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