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SS-Lapachone

CAT: 0498-bs-82478C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82478C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae) . A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD (P) H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C

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